Personalized vaccines: the emerging field of vaccinomics

GA Poland, IG Ovsyannikova… - Expert opinion on …, 2008 - Taylor & Francis
The next 'golden age'in vaccinology will be ushered in by the new science of vaccinomics. In
turn, this will inform and allow the development of personalized vaccines, based on our …

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

EA Said, FP Dupuy, L Trautmann, Y Zhang, Y Shi… - Nature medicine, 2010 - nature.com
Viral replication and microbial translocation from the gut to the blood during HIV infection
lead to hyperimmune activation, which contributes to the decline in CD4+ T cell numbers …

Genetic predisposition to persistent human papillomavirus-infection and virus-induced cancers

H Espinoza, KT Ha, TT Pham, JL Espinoza - Microorganisms, 2021 - mdpi.com
Human papillomaviruses (HPVs) are the most common sexually transmitted pathogens
worldwide and among the more than 200 identified HPV types, approximately 15 high risk …

Interleukin-10 production by tumor infiltrating macrophages plays a role in Human Papillomavirus 16 tumor growth

A Bolpetti, JS Silva, LL Villa, AP Lepique - BMC immunology, 2010 - Springer
Abstract Background Human Papillomavirus, HPV, is the main etiological factor for cervical
cancer. Different studies show that in women infected with HPV there is a positive correlation …

Genetic polymorphisms in tumor necrosis factor alpha and interleukin-10 are associated with an increased risk of cervical cancer

GH Du, JK Wang, JR Richards, JJ Wang - International …, 2019 - Elsevier
Most cases of cervical cancer are the result of infection with specific high-risk types of human
papillomavirus (HPV). Investigating the genetic basis of the host immune response …

Immune responses against virus and tumor in cervical carcinogenesis: treatment strategies for avoiding the HPV-induced immune escape

P Conesa-Zamora - Gynecologic oncology, 2013 - Elsevier
Despite the availability of prophylactic vaccines against human papillomavirus (HPV),
cervical cancer (CC) is still a major problem globally. It is the cancer with the second highest …

Genetics and vaccines in the era of personalized medicine

J Castiblanco, JM Anaya - Current Genomics, 2015 - ingentaconnect.com
Vaccines represent the most successful and sustainable tactic to prevent and counteract
infection. A vaccine generally improves immunity to a particular disease upon administration …

[HTML][HTML] Key considerations and current perspectives of epidemiological studies on human papillomavirus persistence, the intermediate phenotype to cervical cancer

SL Sudenga, S Shrestha - International Journal of Infectious Diseases, 2013 - Elsevier
Persistent infection with human papillomavirus (HPV) causes essentially all precancerous
cervical lesions and cervical cancer in females and thus is an important intermediate …

The paradox of IL‑10‑mediated modulation in cervical cancer

YAN Wang, XH Liu, YH Li, O Li - Biomedical Reports, 2013 - spandidos-publications.com
Abstract Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially
cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent. The role of IL-10 …

Interleukin-10− 1082 gene polymorphism and susceptibility to cervical cancer among Japanese women

K Matsumoto, A Oki, T Satoh, S Okada… - Japanese journal of …, 2010 - academic.oup.com
Polymorphisms in cytokine genes can influence immune responses to human
papillomavirus infection, possibly modifying risks of cervical cancer. Using an amplification …