The blood-brain barrier: Physiology and strategies for drug delivery
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …
reflecting the unique requirements of the brain. In this review, following a brief historical …
[HTML][HTML] Ultrasound neuromodulation: a review of results, mechanisms and safety
Ultrasonic neuromodulation is a rapidly growing field, in which low-intensity ultrasound (US)
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …
is delivered to nervous system tissue, resulting in transient modulation of neural activity. This …
Neuromodulation with single‐element transcranial focused ultrasound in human thalamus
Transcranial focused ultrasound (tFUS) has proven capable of stimulating cortical tissue in
humans. tFUS confers high spatial resolutions with deep focal lengths and as such, has the …
humans. tFUS confers high spatial resolutions with deep focal lengths and as such, has the …
Drug delivery system based on nanobubbles
J Jin, L Yang, F Chen, N Gu - Interdisciplinary Materials, 2022 - Wiley Online Library
Ultrasound (US) medical technology is widely used due to its advantages of safety, speed,
and low cost. With the rapid development of biomedical nanotechnology …
and low cost. With the rapid development of biomedical nanotechnology …
BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging
Intracerebral vector delivery in nonhuman primates has been a major challenge. We report
successful blood-brain barrier opening and focal delivery of adeno-associated virus …
successful blood-brain barrier opening and focal delivery of adeno-associated virus …
Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies
Y Meng, CB Pople, H Lea-Banks, A Abrahao… - Journal of controlled …, 2019 - Elsevier
The blood-brain barrier, while fundamental in maintaining homeostasis in the central
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …
nervous system, is a bottleneck to achieving efficacy for numerous therapeutics. Improved …
[HTML][HTML] Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates
An emerging approach with potential in improving the treatment of neurodegenerative
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …
diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain …
[HTML][HTML] Focused ultrasound for neuromodulation
DP Darrow - Neurotherapeutics, 2019 - Elsevier
For more than 70 years, the promise of noninvasive neuromodulation using focused
ultrasound has been growing while diagnostic ultrasound established itself as a foundation …
ultrasound has been growing while diagnostic ultrasound established itself as a foundation …
[HTML][HTML] Probing the pressure dependence of sound speed and attenuation in bubbly media: Experimental observations, a theoretical model and numerical …
The problem of attenuation and sound speed of bubbly media has remained partially
unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation …
unsolved. Comprehensive data regarding pressure-dependent changes of the attenuation …
[HTML][HTML] Focused ultrasound and microbubbles-mediated drug delivery to brain tumor
The presence of blood–brain barrier (BBB) and/or blood–brain–tumor barriers (BBTB) is one
of the main obstacles to effectively deliver therapeutics to our central nervous system (CNS); …
of the main obstacles to effectively deliver therapeutics to our central nervous system (CNS); …