Extensive research has been undertaken in the pursuit of anticancer therapeutics. Many
anticancer drugs require specificity of delivery to cancer cells, whilst sparing healthy tissue …

The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …

The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Modifying cyclic cell‐penetrating deca‐arginine (cR10) peptides with 4‐(4‐
dimethylaminophenylazo) benzoic acid (DABCYL) improves the uptake efficiency of …

Biophysical studies have a very high impact on the understanding of internalization,
molecular mechanisms, interactions, and localization of CPPs and CPP/cargo conjugates in …

The development of cell-penetrating polymers with endocytosis-independent cell uptake
pathways has emerged as a prominent strategy to enhance the transfection efficiency …

In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short
overview of CPP history and discuss several aspects of CPP classification. Next section is …

Every cell biological textbook teaches us that the main role of the plasma membrane is to
separate cells from their neighborhood to allow for a controlled composition of the …

The bone microenvironment provides a “barrier” for bone tumors to resist clinical
chemoradiotherapy, implying that molecules targeting tumor cells alone cannot effectively …

Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic
cells and their compartments. The alteration of their composition, structure, and morphology …