Histone deacetylases (HDACs) are epigenetic regulators that regulate the histone tail,
chromatin conformation, protein-DNA interaction, and even transcription. HDACs are also …

Histone deacetylases (HDACs) play an important role in regulating target gene expression.
They have been highlighted as a novel category of anticancer targets, and their inhibition …

The idea that inherited genotypes define phenotypes has been paramount in modern
biology. The question remains, however, whether stable phenotypes could be also inherited …

We have carried out a cell-based screen aimed at discovering small molecules that activate
p53 and have the potential to decrease tumor growth. Here, we describe one of our hit …

Stably enhanced histone acetylation has long been regarded as a condition of
transcriptionally active genes. Recent papers suggest a more dynamic model, with rapid …

Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

Histone methylation regulates diverse chromatin-templated processes, including
transcription. Many transcriptional corepressor complexes contain lysine-specific …

Lysine-specific demethylase 1 (LSD1) was recently identified as the first histone
demethylase that specifically demethylates monomethylated and dimethylated histone H3 at …

Fungal secondary metabolites are important bioactive compounds but the conditions
leading to expression of most of the putative secondary metabolism (SM) genes predicted by …

Histone deacetylases (HDACs)—an enzyme family that deacetylates histones and non‐
histone proteins—are implicated in human diseases such as cancer, and the first …