Oncolytic viruses represent a novel drug class in which native or modified viruses mediate
tumor regression through selective replication within and lysis of tumor cells as well as …

There is a growing attention toward personalized medicine. This is led by a fundamental
shift from the 'one size fits all'paradigm for treatment of patients with conditions or …

Abstract Purpose: Sabatolimab (MBG453) and spartalizumab are mAbs that bind T-cell
immunoglobulin domain and mucin domain-3 (TIM-3) and programmed death-1 (PD-1) …

PURPOSE KEYNOTE-158 (ClinicalTrials. gov identifier: NCT02628067) is a phase II basket
study investigating the antitumor activity and safety of pembrolizumab in multiple cancer …

This selection from the NCCN Guidelines for Non–Small Cell Lung Cancer (NSCLC)
focuses on targeted therapies and immunotherapies for metastatic NSCLC, because …

Purpose Stereotactic body radiotherapy (SBRT) may stimulate innate and adaptive immunity
to augment immunotherapy response. Multisite SBRT is an emerging paradigm for treating …

PURPOSE Anaplastic thyroid carcinoma is an aggressive malignancy that is almost always
fatal and lacks effective systemic treatment options for patients with BRAF-wild type disease …

Purpose The KEYNOTE-028 trial (ClinicalTrials. gov identifier: NCT02054806) was
designed to assess the safety and efficacy of pembrolizumab in 20 programmed death …

Purpose To establish the safety profile and antitumor activity of the anti–programmed death
1 receptor monoclonal antibody, pembrolizumab, in patients with recurrent or metastatic …

Background Anti-programmed cell death receptor-1 (PD-1) antibodies represent an effective
treatment option for metastatic melanoma as well as for other cancer entities. They act via …