The molecular mechanisms underlying major depressive disorder remain poorly
understood, and current antidepressant treatments have many shortcomings. The recent …

Major depressive disorder (MDD) is a common psychiatric illness that manifests in sex-
influenced ways. Men and women may experience depression differently and also respond …

Perineuronal nets (PNNs), components of the extracellular matrix, preferentially coat
parvalbumin-positive interneurons and constrain critical-period plasticity in the adult …

Within the scope of the 3Rs of Russel and Burch, the number of laboratory animals can be
reduced by repeated use of an animal. This strategy only becomes relevant, if the total …

Ketamine is shown to enhance excitatory synaptic drive in multiple brain areas, which is
presumed to underlie its rapid antidepressant effects. Moreover, ketamine's therapeutic …

Ketamine, a dissociative anesthetic and psychedelic compound, has revolutionized the field
of psychopharmacology by showing robust, and rapid-acting antidepressant activity in …

Background While ketamine has been increasingly studied for treatment resistant
depression (TRD), the impact of sex differences on treatment outcomes has not been well …

In this review, we will discuss the safety of repeated treatments with ketamine for patients
with treatment-resistant depression (TRD), a condition in which patients with major …

Discovering that the anesthetic drug ketamine has rapidly acting antidepressant effects in
many individuals with major depression is one of the most important findings in clinical …

Some studies have demonstrated that ascorbic acid, similarly to ketamine, exhibits
antidepressant-like effects mediated, at least in part, by modulation of the glutamatergic …