Designer drugs: mechanism of action and adverse effects

D Luethi, ME Liechti - Archives of toxicology, 2020 - Springer
Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

From PCP to MXE: a comprehensive review of the non‐medical use of dissociative drugs

H Morris, J Wallach - Drug testing and analysis, 2014 - Wiley Online Library
PCP or phencyclidine was discovered in 1956 and soon became a popular street drug.
Dissociatives including PCP, ketamine, and dextromethorphan have been used non …

Reports of adverse events associated with use of novel psychoactive substances, 2013–2016: a review

BK Logan, ALA Mohr, M Friscia… - Journal of Analytical …, 2017 - academic.oup.com
Novel psychoactive substances (NPS) represent significant analytical and interpretive
challenges to forensic and clinical toxicologists. Timely access to case reports and reports of …

Management of pharmaceutical and recreational drug poisoning

B Mégarbane, M Oberlin, JC Alvarez, F Balen… - Annals of intensive …, 2020 - Springer
Background Poisoning is one of the leading causes of admission to the emergency
department and intensive care unit. A large number of epidemiological changes have …

Next generation of novel psychoactive substances on the horizon–A complex problem to face

JB Zawilska, D Andrzejczak - Drug and Alcohol Dependence, 2015 - Elsevier
Background The last decade has seen a rapid and continuous growth in the availability and
use of novel psychoactive substances (NPS) across the world. Although various products …

Novel psychoactive substances: types, mechanisms of action, and effects

DK Tracy, DM Wood, D Baumeister - Bmj, 2017 - bmj.com
In 2016 the Psychoactive Substances Bill banned trading but not possession of all current
and future novel psychoactive substances (NPS), sometimes incorrectly called “legal highs,” …

The ketamine analogue methoxetamine and 3-and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor

BL Roth, S Gibbons, W Arunotayanun, XP Huang… - PloS one, 2013 - journals.plos.org
In this paper we determined the pharmacological profiles of novel ketamine and
phencyclidine analogues currently used as 'designer drugs' and compared them to the …

Legal highs: staying on top of the flood of novel psychoactive substances

D Baumeister, LM Tojo… - Therapeutic advances in …, 2015 - journals.sagepub.com
There has been growing clinical, public, and media awareness and concern about the
availability and potential harmfulness of so-called 'legal highs', which are more appropriately …

From “Special K” to “Special M”: the evolution of the recreational use of ketamine and methoxetamine

O Corazza, S Assi, F Schifano - CNS neuroscience & …, 2013 - Wiley Online Library
This article reviews the recreational use of ketamine (“Special K”; KET) and explores the
recent diffusion of its new derivative methoxetamine (“Special M”; MXE). The literature …

Multicomponent LC–MS/MS screening method for detection of new psychoactive drugs, legal highs, in urine—experience from the Swedish population

Y Al-Saffar, NN Stephanson, O Beck - Journal of Chromatography B, 2013 - Elsevier
The advent of new not yet legally regulated psychoactive substances sold over the Internet
has created a challenge for clinical toxicology and drug testing laboratories. The routine use …