Asthma is a complex inflammatory disease characterized by airway inflammation and
hyperresponsiveness. The mechanisms associated with the development and progression …

The respiratory tract has an approximate surface area of 70 m2 in adult humans, which is in
virtually direct contact with the outside environment. It contains a uniquely rich vascular bed …

The method of choice for the development of new vaccines is to target distinct dendritic cell
subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated …

Asthma is characterized by chronic inflammation of the airways in which there is an
overabundance of eosinophils, mast cells, and activated T helper lymphocytes. These …

The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a
consequence of their localization within tissues and their specialized capacity for …

To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-
1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies …

Rationale: The pulmonary mononuclear phagocyte system is a critical host defense
mechanism composed of macrophages, monocytes, monocyte-derived cells, and dendritic …

Innate mononuclear phagocytic system (MPS) cells preserve mucosal immune homeostasis.
We investigated their role at nasal mucosa following allergen challenge with house dust …

Advances have been made in defining the mechanisms for the control of allergic airway
inflammation in response to inhaled antigens. Several genes, including ADAM33, DPP10 …

Studies of human lung development have focused on epithelial and mesenchymal cell types
and function, but much less is known about the developing lung immune cells, even though …