Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing
Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …
Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
membraneless compartments to ensure that a wide variety of cellular activities occur in a …
Autophagy induction as a therapeutic strategy for neurodegenerative diseases
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …
contents to lysosomes for degradation. Genetic studies have revealed extensive links …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
Droplet physics and intracellular phase separation
F Jülicher, CA Weber - Annual Review of Condensed Matter …, 2024 - annualreviews.org
Living cells are spatially organized by compartments that can nucleate, grow, and dissolve.
Compartmentalization can emerge by phase separation, leading to the formation of droplets …
Compartmentalization can emerge by phase separation, leading to the formation of droplets …
Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles
Membraneless organelles contain a wide spectrum of molecular chaperones, indicating
their important roles in modulating the metastable conformation and biological function of …
their important roles in modulating the metastable conformation and biological function of …
Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders
M Boivin, V Pfister, A Gaucherot, F Ruffenach… - The EMBO …, 2020 - embopress.org
Expansion of G4C2 repeats within the C9ORF72 gene is the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Such repeats lead …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Such repeats lead …
[PDF][PDF] The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUS
Formation of biomolecular condensates through liquid-liquid phase separation (LLPS) has
emerged as a pervasive principle in cell biology, allowing compartmentalization and …
emerged as a pervasive principle in cell biology, allowing compartmentalization and …
The liquid state of FG-nucleoporins mimics permeability barrier properties of nuclear pore complexes
G Celetti, G Paci, J Caria, V VanDelinder… - Journal of Cell …, 2019 - rupress.org
Nuclear pore complexes (NPCs) regulate all cargo traffic across the nuclear envelope. The
transport conduit of NPCs is highly enriched in disordered phenylalanine/glycine-rich …
transport conduit of NPCs is highly enriched in disordered phenylalanine/glycine-rich …
The complex mechanisms by which neurons die following DNA damage in neurodegenerative diseases
Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …