Since the definition of the “12 Principles of Green Chemistry” more than 20 years ago,
chemists have become increasingly mindful of the need to conserve natural resources and …

C–H functionalization reactions are playing an increasing role in the preparation and
modification of complex organic molecules, including pharmaceuticals, agrochemicals and …

In industries and academic laboratories, several late transition metal-catalyzed prerequisite
reactions are widely performed during single and multistep synthesis. However, besides the …

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with
notable applications to material sciences, crop protection, drug discovery, and …

Despite decades of ground-breaking research in academia, organic synthesis is still a rate-
limiting factor in drug-discovery projects. Here we present some current challenges in …

The term late-stage functionalization (LSF) is recent but is now frequently used in the field of
organic methodology development to describe transformations on complex molecules. Such …

The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …

The atomistic change of C (sp3)–H to C (sp3)–O can have a profound impact on the physical
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …

The advent of modern C–H functionalization chemistries has enabled medicinal chemists to
consider a synthetic strategy, late stage functionalization (LSF), which utilizes the C–H …

The current status of homogeneous iron catalysis in organic chemistry is contemplated, as
are the reasons why this particular research area only recently starts challenging the …