Tendon healing is characterized by the formation of fibrovascular scar tissue, as tendon has
very little intrinsic regenerative capacity. This creates a substantial clinical challenge in the …

According to “Wolff's Law”, bone is deposited and reinforced at areas of greatest stress.
From a clinical perspective, this “law” is supported by the strong association between bone …

The extracellular matrix is critical in guiding cell behavior in normal and pathologic tissues,
particularly in cancers and fibrosis. Highlighting the organization (or disorganization) of a …

The microscopic examination of fossilized bone tissue is a sophisticated and increasingly
important analytical tool for understanding the life history of ancient organisms. This book …

Rapid bone regeneration within a three-dimensional defect without the use of bone grafts,
exogenous growth factors, or cells remains a major challenge. We report here on the use of …

Bone's remarkable mechanical properties are a result of its hierarchical structure. The
mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's …

Bone modeling is a mechanically mediated adaptive process for changing a bone's size,
shape, or position. Site specific, anabolic and catabolic modeling events are manifestations …

The secondary osteon—a fundamental building block in compact bone—is a multilayered
cylindrical structure of mineralized collagen fibrils arranged around a blood vessel …

Bone strength and failure are increasingly thought to be due to ultrastructural properties,
such as the morphology of the lacuno-canalicular network, the collagen fiber orientation and …

Antlers are bony appendages of deer that undergo periodic regeneration from the top of
permanent outgrowths (the pedicles) of the frontal bones. Of the “less familiar” bone types …