Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

Inflammatory bowel diseases (IBD) can be broadly divided into Crohn's disease (CD) and
ulcerative colitis (UC) from their clinical phenotypes. Over 150 host susceptibility genes have …

Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Gut inflammation is strongly associated with spondyloarthritis (SpA), as exemplified by the
high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
results in significant neurodegeneration in the majority of those affected and is a common …

Macrophages, which are functional plasticity cells, have the ability to phagocytize and digest
foreign substances and acquire pro-(M1-like) or anti-inflammatory (M2-like) phenotypes …

Dendritic cells (DCs) mediate tolerance to food antigens, limit reactivity to the gut microbiota
and are required for optimal response to intestinal pathogens. Intestinal DCs are …

Although tissue-resident memory T cells (TRM cells) have been shown to regulate host
protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains …