Protein-protein interactions (PPIs) are well-established as a class of promising drug targets
for their implications in a wide range of biological processes. However, drug development …

Toll-like receptors (TLRs) are type I transmembrane proteins that are key regulators of both
innate and adaptive immune responses. To protect the host from viral and bacterial threats …

Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced
analgesia and contributing to various unwanted actions. How this occurs is unknown but has …

ABSTRACT Introduction Protein-protein interactions (PPIs) have been often considered
undruggable targets although they are attractive for the discovery of new therapeutics. The …

A cell-based high-throughput screen to identify small molecular weight stimulators of the
innate immune system revealed substituted pyrimido [5, 4-b] indoles as potent NFκB …

Protein− protein interactions (PPIs) are critical in numerous biological processes including
signaling transduction, function regulations, and disease development. To regulate PPIs has …

As an essential part of many biological processes, protein–protein interactions (PPIs) offer
exciting and promising opportunities for drug discovery by extension of the druggable target …

Toll‐like receptors (TLRs) have been shown to play an important role in the immune system,
which warrants study of their remarkable potential as pharmacological targets. Activation of …

Background The development of antinociceptive tolerance following repetitive
administration of opioid analgesics significantly hinders their clinical use. Evidence has …

Repeat proteins are increasingly attracting much attention as alternative scaffolds to
immunoglobulin antibodies due to their unique structural features. Nonetheless, engineering …