Glioblastoma (GBM) is the most invasive and deadliest brain cancer in adults. Its inherent
heterogeneity has been designated as the main cause of treatment failure. Thus, a deeper …

Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

Glioma is the most common type of primary CNS tumor, composed of cells that resemble
normal glial cells. Recent genetic studies have provided insight into the inter-tumoral …

Background Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in
cancer therapy, only a limited fraction of patients benefit from it. Cancer stemness can be the …

Glioblastoma tumors exhibit extensive inter-and intratumoral heterogeneity, which has
contributed to the poor outcomes of numerous clinical trials and continues to complicate the …

Background Glioblastoma (GBM) is the most aggressive type of primary brain tumor and is
often resistant to current therapies. Tumor microenvironment-centered therapies may …

Objectives Circadian rhythm controls complicated physiological activities in organisms.
Circadian clock genes have been related to tumour progression, but its role in glioma is …

Human cerebral cancers are known to contain cell types resembling the varying stages of
neural development. However, the basis of this association remains unclear. Here, we map …

Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

Cell motility is critical for tumor malignancy. Metabolism being an obligatory step in shaping
cell behavior, we looked for metabolic weaknesses shared by motile cells across the diverse …