Recent advancements and developments in search of anti-tuberculosis agents: a quinquennial update and future directions
Tuberculosis (TB) has been considered as the highly chronic, contagious and infectious
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
disorder caused by Mycobacterium tuberculosis (Mtb). Every year more than 10 million …
Recent investigations into synthesis and pharmacological activities of phenoxy acetamide and its derivatives (chalcone, indole and quinoline) as possible therapeutic …
FH Al-Ostoot, Zabiulla, S Salah, SA Khanum - Journal of the Iranian …, 2021 - Springer
Medicinal chemistry can rightfully be regarded as a cornerstone in the public health of our
modern society that combines chemistry and pharmacology with the aim of designing and …
modern society that combines chemistry and pharmacology with the aim of designing and …
Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno [2, 3-d] pyrimidine-acetamide molecular hybrids as potential …
Malaria is the most lethal parasitic infections in the world. To address the emergence of drug
resistance to current antimalarials, here we report the design and synthesis of new series of …
resistance to current antimalarials, here we report the design and synthesis of new series of …
Synthesis and potential antimicrobial activity of novel α-aminophosphonates derivatives bearing substituted quinoline or quinolone and thiazole moieties
To develop novel antimicrobial agents, and based on the biologically active heterocyclic
quinoline and thiazole substituted, a series of novel α-aminophosphonates (9a–h) and (10i …
quinoline and thiazole substituted, a series of novel α-aminophosphonates (9a–h) and (10i …
Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene …
Eight Novel chalcones were synthesized and their structures were confirmed by different
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
Synthesis, antimicrobial, and antibiofilm activities of some novel 7-methoxyquinoline derivatives bearing sulfonamide moiety against urinary tract infection-causing …
A new series of 4-((7-methoxyquinolin-4-yl) amino)-N-(substituted) benzenesulfonamide 3
(a–s) was synthesized via the reaction of 4-chloro-7-methoxyquinoline 1 with various sulfa …
(a–s) was synthesized via the reaction of 4-chloro-7-methoxyquinoline 1 with various sulfa …
[HTML][HTML] QSAR modeling, molecular docking and molecular dynamic simulation of phosphorus-substituted quinoline derivatives as topoisomerase I inhibitors
M Lahyaoui, H El-Idrissi, T Saffaj, B Ihssane… - Arabian Journal of …, 2023 - Elsevier
As they facilitate the cleavage of single and double stranded DNA to relax supercoils,
unwind catenanes, and condense chromosomes in eukaryotic cells, Topoisomerase plays …
unwind catenanes, and condense chromosomes in eukaryotic cells, Topoisomerase plays …
Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic insights
Emergence of antimicrobial resistance has become a great threat to human species as there
is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR …
is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR …
Novel synthesis of quinoline chalcone derivatives-Design, synthesis, characterization and antimicrobial activity
CHP Kumar, MS Katagi, BP Nandeshwarappa - Chemical Data Collections, 2022 - Elsevier
In the present study, an easy and conventional method has been adopted for the synthesis
of novel 1-methyl-3-(3-oxo-3-phenylprop-1-enyl) quinoline-2-(1H)-ones (5a–i) by a …
of novel 1-methyl-3-(3-oxo-3-phenylprop-1-enyl) quinoline-2-(1H)-ones (5a–i) by a …
Terminal respiratory oxidases: a targetables vulnerability of mycobacterial bioenergetics?
Recently, ATP synthase inhibitor Bedaquiline was approved for the treatment of multi-drug
resistant tuberculosis emphasizing the importance of oxidative phosphorylation for the …
resistant tuberculosis emphasizing the importance of oxidative phosphorylation for the …