Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …

In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway,
termed the integrated stress response (ISR), to restore cellular homeostasis. The core event …

Cell signaling in response to an array of diverse stress stimuli converges on the
phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2). Phosphorylation of …

MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …

The newly emerging coronavirus SARS-CoV-2 causes severe lung disease and substantial
mortality. How the virus evades host defense for efficient replication is not fully understood …

During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene
expression designed to ameliorate the underlying cellular disturbance. Central to this stress …

In response to environmental stress, cells induce a program of gene expression designed to
remedy cellular damage or, alternatively, induce apoptosis. In this report, we explore the role …

It is not known how influenza A viruses, important human pathogens, counter PKR
activation, a crucial host antiviral response. Here we elucidate this mechanism. We show …

Herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2) have co-evolved with humans for
thousands of years and are present at a high prevalence in the population worldwide. HSV …

Phosphorylation of eukaryotic initiation factor-2 (eIF2) by pancreatic eIF2 kinase (PEK),
induces a program of translational expression in response to accumulation of malfolded …