A large number of chemicals and several physical agents, such as UV light and γ-radiation,
have been associated with the etiology of human cancer. Generation of DNA damage (also …

The MAPK cascade plays a crucial role in tumor cell proliferation and survival. Accumulating
evidence suggests that mutations in the BRAF oncogene are not only associated with poor …

BACKGROUND: The CRYSTAL and OPUS randomised clinical trials demonstrated that
adding cetuximab to first-line chemotherapy in patients with KRAS wild-type metastatic …

Circulating tumor cells (CTCs) provide a readily accessible source of tumor material from
patients with cancer. Molecular profiling of these rare cells can lead to insight on disease …

Abstract Background The phase III EXTREME study demonstrated that combining cetuximab
with platinum/5-fluorouracil (5-FU) significantly improved overall survival in the first-line …

Background Findings from the phase 3 FLEX study showed that the addition of cetuximab to
cisplatin and vinorelbine significantly improved overall survival, compared with cisplatin and …

MicroRNA (miRNA)-binding site polymorphisms that could contribute to disease risk and
prognosis are rapidly being identified and investigated as this genetic variation may have a …

Overexpression of the epidermal growth factor receptor (EGFR) is a common characteristic
of head and neck squamous cell carcinomas (HNSCC). Cetuximab is a chimeric anti-EGFR …

Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In
certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic …

Colorectal cancer is one common digestive malignancy, and the most common approach of
blood metastasis of colorectal cancer is through the portal vein system to the liver. Early …