Epilepsy involves neuronal dysfunction at molecular, cellular, and circuit levels. The
understanding of the mechanism of the epilepsies has advanced greatly in the last three …

Deep Brain Stimulation (DBS) has evolved into a well-accepted add-on treatment for
patients with severe Parkinsons disease as well as for other chronic neurological conditions …

Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …

The precise circuit of the substantia nigra pars reticulata (SNr) involved in temporal lobe
epilepsy (TLE) is still unclear. Here we found that optogenetic or chemogenetic activation of …

Mesial temporal lobe epilepsy (MTLE) is the most common form of focal, pharmacoresistant
epilepsy in adults and is often associated with hippocampal sclerosis. Here, we established …

Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic
oscillations. However, direct intervention of the hippocampus, the most prevalent seizure …

Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

Background Previous studies indicated the involvement of cholinergic neurons in seizure;
however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in …

Neural degeneration and regeneration are important topics in neurological diseases. There
are limited options for therapeutic interventions in neurological diseases that provide …

Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the
most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows …