Activation of cyclin-dependent kinases in higher eukaryotic cells can be achieved through
dephosphorylation by members of the Cdc25 phosphatase family, Cdc25A, Cdc25B and …

▪ Abstract The initiation of DNA replication in eukaryotic cells is tightly controlled to ensure
that the genome is faithfully duplicated once each cell cycle. Genetic and biochemical …

Control of eukaryotic cell proliferation involves an extended regulatory network, the
complexity of which has made it difficult to understand the basic principles of the cell cycle …

The conserved protein kinase Chk1 is believed to play an important role in checkpoint
responses to aberrant DNA structures; however, genetic analysis of Chk1 functions in …

The protein kinases ATM and ATR are central components of the checkpoint mechanisms
that signal the presence of damaged DNA and stalled replication forks. Recent studies have …

In the fission yeast Schizosaccharomyces pombe, the protein kinase Cds1 is activated by
the S–M replication checkpoint that prevents mitosis when DNA is incompletely replicated …

Wee1-related kinases function in a highly conserved mechanism that controls the timing of
entry into mitosis. Loss of Wee1 function causes fission yeast and budding yeast cells to …

Recent work on the mechanisms of DNA damage and replication cell cycle checkpoints has
revealed great similarity between the checkpoint pathways of organisms as diverse as …

We have used time-lapse fluorescence microscopy to study the properties of the Cdc25B
and Cdc25C phosphatases that have both been implicated as initiators of mitosis in human …

Studies of the genetics of G2/M checkpoints in budding and fission yeasts have produced
many of the defining concepts of checkpoint biology. Recent progress in the biochemistry of …