Effectiveness of the CoronaVac vaccine in older adults during a gamma variant associated epidemic of covid-19 in Brazil: test negative case-control study

OT Ranzani, MDT Hitchings, M Dorion, TL D'Agostini… - bmj, 2021 - bmj.com
Objective To estimate the effectiveness of the inactivated whole virus vaccine, CoronaVac
(Sinovac Biotech), against symptomatic covid-19 in the elderly population of São Paulo …

Heterologous AD5-nCOV plus CoronaVac versus homologous CoronaVac vaccination: a randomized phase 4 trial

J Li, L Hou, X Guo, P Jin, S Wu, J Zhu, H Pan… - Nature medicine, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and the waning of vaccine-elicited neutralizing antibodies suggests that additional …

[HTML][HTML] Estimated number of deaths directly averted in people 60 years and older as a result of COVID-19 vaccination in the WHO European Region, December 2020 …

MMI Meslé, J Brown, P Mook, J Hagan… - …, 2021 - eurosurveillance.org
Since December 2019, over 1.5 million SARS-CoV-2-related fatalities have been recorded
in the World Health Organization European Region-90.2% in people≥ 60 years. We …

Genomic epidemiology of the SARS-CoV-2 epidemic in Brazil

M Giovanetti, SN Slavov, V Fonseca, E Wilkinson… - Nature …, 2022 - nature.com
The high numbers of COVID-19 cases and deaths in Brazil have made Latin America an
epicentre of the pandemic. SARS-CoV-2 established sustained transmission in Brazil early …

Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control …

MDT Hitchings, OT Ranzani, MSS Torres… - The Lancet Regional …, 2021 - thelancet.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant,
Gamma, emerged in the city of Manaus in late 2020 during a large resurgence of …

Saliva is suitable for SARS-CoV-2 antibodies detection after vaccination: A rapid systematic review

ENS Guerra, VT Castro, J Amorim dos Santos… - Frontiers in …, 2022 - frontiersin.org
Since the introduction of efficient vaccines anti-SARS-CoV-2, antibody quantification
becomes increasingly useful for immunological monitoring and COVID-19 control. In several …

Saving millions of lives but some resources squandered: emerging lessons from health research system pandemic achievements and challenges

SR Hanney, SE Straus, BJ Holmes - Health Research Policy and Systems, 2022 - Springer
During the SARS-CoV-2 pandemic, astonishingly rapid research averted millions of deaths
worldwide through new vaccines and repurposed and new drugs. Evidence use informed …

Influence of age on the effectiveness and duration of protection of Vaxzevria and CoronaVac vaccines: A population-based study

T Cerqueira-Silva, V de Araújo Oliveira… - The Lancet Regional …, 2022 - thelancet.com
Background Aging influences COVID-19 severity and response to vaccination, but previous
vaccine effectiveness (VE) analyzes lack the power to evaluate its role in subgroups within …

Matrix metalloproteinases on severe COVID-19 lung disease pathogenesis: cooperative actions of MMP-8/MMP-2 axis on immune response through HLA-G shedding …

PV da Silva-Neto, VB do Valle, CA Fuzo… - Biomolecules, 2022 - mdpi.com
Patients with COVID-19 predominantly have a respiratory tract infection and acute lung
failure is the most severe complication. While the molecular basis of SARS-CoV-2 …

Estimating averted COVID-19 cases, hospitalisations, intensive care unit admissions and deaths by COVID-19 vaccination, Italy, January− September 2021

C Sacco, A Mateo-Urdiales, D Petrone… - …, 2021 - eurosurveillance.org
We assessed the impact of COVID-19 vaccination in Italy, by estimating numbers of averted
COVID-19 cases, hospitalisations, ICU admissions and deaths between January and …