Chimeric antigen receptor T-cell and bispecific antibody therapy in multiple myeloma: moving into the future

SA Holstein, SJ Grant, TM Wildes - Journal of Clinical Oncology, 2023 - ascopubs.org
Historically, the outcomes for individuals with triple-class refractory and penta-drug refractory
multiple myeloma (MM) have been poor because of a dearth of effective treatment options …

Access to CAR T-cell therapy: Focus on diversity, equity and inclusion

MS Odstrcil, CJ Lee, C Sobieski, D Weisdorf, D Couriel - Blood Reviews, 2024 - Elsevier
Chimeric antigen receptor T-cell (CAR T-cell) therapy has revolutionized the treatment of
hematologic malignancies in patients with relapsed or refractory disease without other …

CAR T-cell therapy for patients with multiple myeloma: current evidence and challenges

MJ Rendo, JJ Joseph, LM Phan… - Blood and lymphatic …, 2022 - Taylor & Francis
The therapeutic landscape of multiple myeloma (MM) has benefited from an emergence of
novel therapies over the last decade. By inducing T-cell kill of target cancer cells, chimeric …

Trends in volumes and survival after hematopoietic cell transplantation in racial/ethnic minorities

N Khera, S Ailawadhi, R Brazauskas, J Patel… - Blood …, 2024 - ashpublications.org
There has been an increase in volume as well as an improvement in overall survival (OS)
after hematopoietic cell transplantation (HCT) for hematologic disorders. It is unknown if …

Optimizing the manufacturing and antitumour response of CAR T therapy

Y Liu, AS Sperling, EL Smith, DJ Mooney - Nature Reviews …, 2023 - nature.com
Adoptive transfer of naturally occurring or genetically engineered T cells is an effective
treatment for certain haematological malignancies, such as non-Hodgkin lymphoma and …

Access to and affordability of CAR T-cell therapy in multiple myeloma: an EBMT position paper

N Gagelmann, A Sureda, S Montoto, J Murray… - The Lancet …, 2022 - thelancet.com
Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapeutic approach
in the treatment of multiple myeloma, and the recent approval of the first two CAR T-cell …

[HTML][HTML] Overcoming barriers to referral for chimeric antigen receptor T cell therapy in patients with relapsed/refractory diffuse large B cell lymphoma

MS Hoffmann, BD Hunter, PW Cobb, JC Varela… - … and Cellular Therapy, 2023 - Elsevier
Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin
lymphoma. Although outcomes to frontline therapy are encouraging, patients who are …

[HTML][HTML] Mechanisms of resistance and treatment of relapse after CAR T-cell therapy for large B-cell lymphoma and multiple myeloma

K Rejeski, MD Jain, EL Smith - Transplantation and Cellular Therapy, 2023 - Elsevier
Although chimeric antigen receptor (CAR) T cell therapy (CAR-T) has altered the treatment
landscape for relapsed/refractory B cell malignancies and multiple myeloma, only a minority …

The impact of race, ethnicity, and obesity on CAR T-cell therapy outcomes

AJ Faruqi, JA Ligon, P Borgman, SM Steinberg… - Blood …, 2022 - ashpublications.org
Cancer outcomes with chemotherapy are inferior in patients of minority racial/ethnic groups
and those with obesity. Chimeric antigen receptor (CAR) T-cell therapy has transformed …

Disparities in relapsed or refractory multiple myeloma: recommendations from an interprofessional consensus panel

R Banerjee, Y Biru, CE Cole, B Faiman, S Midha… - Blood cancer …, 2024 - nature.com
Many studies have documented racial, socioeconomic, geographic, and other disparities for
United States (US) patients with multiple myeloma pertaining to diagnosis and frontline …