Gut microbiota interact with the brain through systemic chronic inflammation: implications on neuroinflammation, neurodegeneration, and aging

Y Mou, Y Du, L Zhou, J Yue, X Hu, Y Liu… - Frontiers in …, 2022 - frontiersin.org
It has been noticed in recent years that the unfavorable effects of the gut microbiota could
exhaust host vigor and life, yet knowledge and theory are just beginning to be established …

Immune cells in the BBB disruption after acute ischemic stroke: targets for immune therapy?

Y Qiu, C Zhang, A Chen, H Wang, Y Zhou… - Frontiers in …, 2021 - frontiersin.org
Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

Inflammatory responses after ischemic stroke

JH DeLong, SN Ohashi, KC O'Connor… - Seminars in …, 2022 - Springer
Ischemic stroke generates an immune response that contributes to neuronal loss as well as
tissue repair. This is a complex process involving a range of cell types and effector …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
Stroke is currently one of the most common causes of death and disability in the world, and
its pathophysiology is a complex process, involving the oxidative stress and inflammatory …

Embryonic stem cell derived small extracellular vesicles modulate regulatory T cells to protect against ischemic stroke

Y Xia, G Hu, Y Chen, J Yuan, J Zhang, S Wang, Q Li… - ACS …, 2021 - ACS Publications
Stem cell derived small extracellular vesicles (sEVs) have been proved to promote
neurological recovery after stroke. Recent studies demonstrate a phenomenal tissue repair …

Blood-brain barrier: more contributor to disruption of central nervous system homeostasis than victim in neurological disorders

M Xiao, ZJ Xiao, B Yang, Z Lan, F Fang - Frontiers in Neuroscience, 2020 - frontiersin.org
The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular
system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by …

Regulatory T cells in ischemic stroke

H Wang, J Ye, L Cui, S Chu, N Chen - Acta Pharmacologica Sinica, 2022 - nature.com
Recent evidence shows that when ischemic stroke (IS) occurs, the BBB would be destructed,
thereby promoting the immune cells to migrate into the brain, suggesting that the immune …

T cell response in ischemic stroke: from mechanisms to translational insights

D Zhang, J Ren, Y Luo, Q He, R Zhao, J Chang… - Frontiers in …, 2021 - frontiersin.org
Ischemic stroke, caused by a sudden disruption of blood flow to the brain, is a leading cause
of death and exerts a heavy burden on both patients and public health systems. Currently …

Immune responses in stroke: how the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?

A Rayasam, M Hsu, JA Kijak, L Kissel… - …, 2018 - Wiley Online Library
Stroke is one of the leading causes of death and disability worldwide. The long‐standing
dogma that stroke is exclusively a vascular disease has been questioned by extensive …

[HTML][HTML] Ischemic brain edema: Emerging cellular mechanisms and therapeutic approaches

W Han, Y Song, M Rocha, Y Shi - Neurobiology of Disease, 2023 - Elsevier
Brain edema is one of the most devastating consequences of ischemic stroke. Malignant
cerebral edema is the main reason accounting for the high mortality rate of large …