RNA cleavage is a fundamental host response for controlling viral infections in both plants
and animals (26). In higher vertebrates, this process is often regulated by interferons (IFNs) …

This review describes the contribution of noncytolytic mechanisms to the control of viral
infections with a particular emphasis on the role of cytokines in these processes. It has long …

Abstract The interferon-induced enzymes 2′-5′-oligoadenylate synthetase (OAS) and
RNase L are key components of innate immunity involved in sensory and effector functions …

Many viruses induce hepatitis in humans, highlighting the need to understand the
underlying mechanisms of virus-induced liver pathology. The murine coronavirus, mouse …

The regulation of mRNA decay is a major control point in gene expression. The stability of a
particular mRNA is controlled by specific interactions between its structural elements and …

We have previously shown that hepatitis B virus (HBV) replication is abolished in the liver of
HBV transgenic mice by stimuli that induce alpha/beta interferon (IFN-α/β) in the liver. The …

The interferon (IFN)-induced double-stranded RNA-activated protein kinase PKR mediates
inhibition of protein synthesis through phosphorylation of the α subunit of eukaryotic …

West Nile virus (WNV) is a neurotropic, mosquito-borne flavivirus that can cause lethal
meningoencephalitis. Type I interferon (IFN) plays a critical role in controlling WNV …

Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral
protein capable of inhibiting a broad spectrum of viruses. ISG20 exhibits strong RNase …

Abstract The 2′, 5′-oligoadenylate synthetase (OAS) and its downstream effector RNase
L play important roles in host defense against virus infection. Oas1b, one of the eight Oas1 …