The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose
tissue dysfunction and contributing to obesity-induced inflammation and metabolic …

The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other
metabolic diseases is well documented. However, a possible physiological role for IL-1β in …

Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during
obesity and type 2 diabetes. However, little is known about the nature and function of …

Obesity is associated with altered gut microbiota composition and impaired gut barrier
function. These changes, together with interrelated mesenteric adipose tissue inflammation …

Increasing energy expenditure via induction of adipose tissue browning has become an
appealing strategy to treat obesity and associated metabolic complications. Herein, we …

BACKGROUND Yellow leaf green tea (YLGT) is a new variety of Camellia sinensis (L.) O.
Ktze, which has yellow leaves and the unique qualities of 'three green through three yellow' …

We recently showed that interleukin (IL)-6–type cytokine signaling in adipocytes induces
free fatty acid release from visceral adipocytes, thereby promoting obesity-induced hepatic …

Obesity is a global public health issue. Obesity-related chronic low-grade inflammation
(meta-inflammation) can lead to aberrant adipokine release and promote cardiometabolic …

Fas-mediated apoptosis in the adipose tissue and the liver plays a pivotal role in the onset of
obesity-associated inflammation, insulin resistance, hepatic steatosis, and metabolic …