Cardiovascular disease (CVD) remains the leading cause of mortality globally, so further
investigation is required to identify its underlying mechanisms and potential targets for its …

Sirtuins (SIRTs) represent a class of nicotinamide adenine dinucleotide (NAD+)-dependent
protein deacetylases that exert a crucial role in cellular signal transduction and various …

Precise gene editing in human pluripotent stem cells (hPSCs) holds great promise for
studying and potentially treating human diseases. Both prime editing and base editing avoid …

Acute kidney injury (AKI) is characterized by a sudden decrease in renal function and
impacts growing number of people worldwide. RNA interference (RNAi) showed potential to …

R-loops are trimeric RNA: DNA hybrids that are important physiological regulators of
transcription; however, their aberrant formation or turnover leads to genomic instability and …

Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the
synthesis of selenylated imidazo [2, 1-b] thiazole by using half molar equivalent diorganyl …

Inactivating p53 mutations are the most abundant genetic alterations found in cancer. Here
we show that CRISPR/Cas9-induced double-stranded DNA breaks enrich for cells deficient …

Colorectal cancer (CRC) driven by PTEN deficiency exhibits high risk of metastasis,
advancement of tumor stages and chemotherapy resistance, where no effective therapy has …

The mutant p53Y220C (mutp53Y220C) is frequently observed in numerous tumors,
including pancreatic cancer. The mutation creates a crevice in the DNA binding core domain …

Abstract Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4 (H3K4) methyltransferase
that interacts with WD repeat domain 5 (WDR5) to regulate cell survival, proliferation, and …