Particle size distribution (PSD) is one of the critical attributes of crystals. PSD not only
influences downstream processes but also controls final product performance in …

In-line fluidic devices and mills are often used for controlling crystal size distribution during
crystallization. In this work, we investigated the breakage of organic crystals in three particle …

Obtaining a particle size within the specifications for a pharmaceutical compound in an
industrial crystallization can be a challenging task. The events affecting the final particle size …

A digital-first approach to produce quality particles of an active pharmaceutical ingredient
across crystallisation, washing and drying is presented, minimising material requirements …

Comminution processes play a pivotal role in diverse applications, ranging from food
processing, to mining and materials engineering. The pharmaceutical industry is no …

Purpose Precipitation of amorphous solid dispersions has gained traction in the
pharmaceutical industry given its application to pharmaceuticals with varying …

Automation plays a vital role in reducing development time in the pharmaceutical industry,
both for drug substance (DS) and drug product (DP). Many aspects of crystallization …

This study compares the use of wet milling and indirect ultrasound for promoting nucleation
and controlling the particle size during the continuous crystallization of a hard-to-nucleate …

Crystallization is a commonly used unit operation for separation and purification. During
processing, crystals may break due to mechanical stress, eg, intentionally by milling or …

Continuous crystallization provides advantages of producing solid products of consistent
quality attributes at a small equipment footprint. However, the intrinsic nucleation and growth …