Pyrazinamide (PZA) is a unique antituberculosis (anti-TB) drug that plays a key role in
shortening TB therapy. PZA kills nonreplicating persisters that other TB drugs fail to kill …

Drug resistance in tuberculosis (TB) is a particular problem because the lengthy therapy of
at least 6 months makes patient compliance very difficult, which frequently creates drug …

Pyrazinamide (PZA) is a first-line tuberculosis drug that plays a unique role in shortening the
duration of tuberculosis chemotherapy. PZA is hydrolyzed intracellularly to pyrazinoic acid …

Tuberculosis (TB) recently became the leading infectious cause of death in adults, while
attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance …

Pyrazinamide is an important sterilizing drug that shortens tuberculosis (TB) therapy.
However, the mechanism of action of pyrazinamide is poorly understood because of its …

Persisters are a small fraction of quiescent bacterial cells that survive lethal antibiotics or
stresses but can regrow under appropriate conditions. Persisters underlie persistent and …

Tuberculosis is today amongst the worldwide health threats. As resistant strains of
Mycobacterium tuberculosis have slowly emerged, treatment failure is too often a fact …

Abstract (See the editorial commentary by Dartois, on pages 1827–9.) Background. It is
believed that nonadherence is the proximate cause of multidrug-resistant tuberculosis (MDR …

To be effective, chemotherapy against tuberculosis (TB) must kill the intracellular population
of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments …

Since the discovery of the tubercle bacillus by Robert Koch in 1882 (110), a greater
understanding of the dynamics and survival mechanisms of this pathogen has led to more …