The role of melatonin in the development of postmenopausal osteoporosis

K Yang, X Qiu, L Cao, S Qiu - Frontiers in pharmacology, 2022 - frontiersin.org
Melatonin is an important endogenous hormone that modulates homeostasis in the
microenvironment. Recent studies have indicated that serum melatonin levels are closely …

RNA binding proteins in senescence: a potential common linker for age-related diseases?

A Varesi, LIM Campagnoli, A Barbieri, L Rossi… - Ageing Research …, 2023 - Elsevier
Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Codonopsis pilosula polysaccharides promote osteogenic differentiation and inhibit lipogenic differentiation of rat bone marrow stem cells by activating β-catenin

J Liu, J An, N Jiang, K Yang, C Guan, N Zhao… - Chemico-Biological …, 2023 - Elsevier
Aberrant bone marrow mesenchymal stem cell (BMSC) lineage differentiation leads to
osteoporosis. Codonopsis pilosula polysaccharides (CPPs) have been widely used in …

Highly pluripotent adipose-derived stem cell–enriched nanofat: a novel translational system in stem cell therapy

LA Quintero Sierra, R Biswas, A Conti… - Cell …, 2023 - journals.sagepub.com
Fat graft is widely used in plastic and reconstructive surgery. The size of the injectable
product, the unpredictable fat resorption rates, and subsequent adverse effects make it tricky …

METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m6A level of SIRT1 mRNA

C Wang, R Chen, X Zhu, X Zhang, N Lian - Bone, 2023 - Elsevier
The purpose of this study was to investigate whether METTL14 participated in
ovariectomized (OVX)-induced osteoporosis (OP) in mice by regulating the m 6 A level of …

Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss

DS Yoon, Y Choi, KM Lee, EA Ko, EJ Kim… - Journal of Biomedical …, 2023 - Springer
Background Although mRNA dysregulation can induce changes in mesenchymal stem cell
(MSC) homeostasis, the mechanisms by which post-transcriptional regulation influences …

A framework of biomarkers for skeletal aging: a consensus statement by the Aging Biomarker Consortium

Aging Biomarker Consortium, J Suo, Y Gan, Y Xie… - Life …, 2023 - academic.oup.com
The skeleton is an important structural and metabolic organ in human body, while aging is
the physiological basis for degenerative skeletal diseases. China has the largest aging …

Aging adipose tissue, insulin resistance, and type 2 diabetes

Y Zhao, R Yue - Biogerontology, 2024 - Springer
With the increase of population aging, the prevalence of type 2 diabetes (T2D) is also rising.
Aging affects the tissues and organs of the whole body, which is the result of various …

Bone‐Targeting and Multishelled Oral Eldecalcitol Nanoparticles Improve Osteoporosis by Reconstruction of Osteogenic‐Osteoclastic Homeostasis

L Meng, W Ma, Y Jiang, X Li, M Zhang… - Advanced Functional …, 2024 - Wiley Online Library
Current treatment of postmenopausal osteoporosis (PMOP) focuses on systemic
administration of medication, neglecting to proactively modulate the local microenvironment …

MSI2 Modulates Unsaturated Fatty Acid Metabolism by Binding FASN in Bovine Mammary Epithelial Cells

CC Lyu, Y Meng, HY Che, JL Suo, YT He… - Journal of Agricultural …, 2023 - ACS Publications
The regulation of fatty acid metabolism is crucial for milk flavor and quality. Therefore, it is
important to explore the genes that play a role in fatty acid metabolism and their …