Lipid rafts are tightly packed, cholesterol-and sphingolipid-enriched microdomains within the
plasma membrane that play important roles in many pathophysiologic processes. Rafts have …

Metastasis is a multistep process including dissociation of cancer cells from primary sites,
survival in the vascular system, and proliferation in distant target organs. As a barrier to …

Malignantly transformed cells must alter their metabolic status to stay viable in a harsh
microenvironment and maintain their ability to invade and spread. Anoikis, a specific …

Significance: Cholesterol is a type of lipid that plays a crucial role in building and
maintaining cell membranes, producing certain hormones, and aiding in digestion. The two …

Abstract Background Hepatitis B virus (HBV) has a crucial role in the progression of
hepatocellular carcinoma (HCC). Tumour cells must develop anoikis resistance in order to …

Proper subcellular localization of focal adhesion kinase (FAK) is crucial for many cellular
processes. It remains, however, unclear how FAK activity is regulated at subcellular …

Cancer stem cells (CSC) may take advantage of the Warburg effect-induced siphoning of
metabolic intermediates into de novo fatty acid biosynthesis to increase self-renewal growth …

Background uPAR and MMP-9, which play critical roles in tumor cell invasion, migration and
angiogenesis, have been shown to be associated with lipid rafts. Methods To investigate …

The interaction of amyloid aggregates with the cell plasma membrane is currently
considered among the basic mechanisms of neuronal dysfunction in amyloid …

2-Hydroxypropyl-β-cyclodextrin (HP-β-CyD) is a cyclic oligosaccharide that is widely used
as an enabling excipient in pharmaceutical formulations, but also as a cholesterol modifier …