Highlights•Chronic stress, depression and inflammation have been consistently
linked.•Stress-induced inflammatory states can contribute to treatment resistance.•Ketamine …

Introduction Despite the growing number of different therapeutic options, treatment of
depression is still a challenge. A broader perspective reveals the benefits of bright light …

Depression is a complicated neuropsychiatric condition with an incompletely understood
etiology, making the discovery of effective therapies challenging. Animal models have been …

Chronic stress-induced anxiodepression is a common health problem, however its potential
neurocircuitry mechanism remains unclear. We used behavioral, patch-clamp …

Imaging studies of treatment-resistant depression (TRD) have examined brain activity,
structure, and metabolite concentrations to identify critical areas of investigation in TRD as …

The widespread adoption of selective serotonin reuptake inhibitors (SSRIs) as first-line
pharmacological treatments in the management of clinical depression transformed the …

Objective To explore the factors influencing anhedonia at baseline and use them as
confounding factors. To further investigate the correlation between overt aggression and …

Background Major depressive disorder (MDD) is a heterogeneous group of mood disorders.
A prominent symptom domain is anhedonia narrowly defined as a loss of interest and ability …

Background Anhedonia, the loss of interest and pleasure, is a core symptom of depression
that is resistant to treatment. Anhedonic young people describe a weakened sense of self …

Drugs generally used in major depressive disorder are considered inappropriate for the
more common milder forms. The efficacy of saffron extracts has been demonstrated in mild …