Liver cell transplantation presents clinical benefit in patients with inborn errors of metabolism
as an alternative, or at least as a bridge, to orthotopic liver transplantation. The success of …

Ischemia/reperfusion (I/R) injury is a major obstacle affecting graft function after liver
transplantation. The cause of this injury is multifactorial. A detailed understanding of the …

Objective: To assess a machine perfusion system in rescuing liver grafts from non-heart-
beating donors (NHBD). Summary Background Data: The introduction of extracorporeal liver …

Mitochondrial respiratory function was studied in permeabilized pig liver biopsies. The cell
membrane was permeabilized mechanically in tissue samples of 2–7 mg, for application of a …

AIM OF THE STUDY: Silybum marianum (milk thistle) is a Mediterranean plant that has been
used since Greco-Roman times to treat liver ailments. Silibinin, the most active …

The aim of the study was to investigate whether hypothermic oxygenated liver perfusion after
cold liver preservation resuscitated metabolic parameters and whether this treatment had a …

Transplantation of human hepatocytes has recently been demonstrated as a safe alternative
to partially correct liver inborn errors of metabolism. Cryopreservation remains the most …

Background & Aims Hypothermic oxygenated machine perfusion (HOPE) is a promising
technique for providing oxygen to the liver during graft preservation; however, because of …

BACKGROUND: We investigated the benefit of two different techniques for resuscitating
marginally preserved liver grafts, unexpectedly subjected to long storage times. METHODS …

Hyperthermic stress is known to protect against myocardial dysfunction after ischemia-
reperfusion injury. It is unclear however, what energetic mechanisms are affected by the …