Aging constitutes the main risk factor for the development of neurodegenerative diseases.
This represents a major health issue worldwide that is only expected to escalate due to the …

The abnormal accumulation of amyloid-β (Aβ) in the central nervous system is a hallmark of
Alzheimer's disease (AD). The regulation of the processing of the single-transmembrane …

Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …

Abstract Alzheimer's disease (AD), which is predicted to affect 1 in 85 persons worldwide by
2050, results in progressive loss of neuronal functions, leading to impairments in memory …

Fyn is a non-receptor or cytoplasmatic tyrosine kinase (TK) belonging to the Src family
kinases (SFKs) involved in multiple transduction pathways in the central nervous system …

Background Alzheimer's disease (AD) is one of the most common causes of dementia in old
people. Neuronal deficits such as loss of memory, language and problem-solving are …

Fyn is a non-receptor tyrosine kinase belonging to the Src family of kinases (SFKs) which
has been implicated in several integral functions throughout the central nervous system …

Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Alzheimer's disease (AD) is an incurable neurodegenerative disorder with a few early
detection strategies. We previously proposed the amyloid precursor protein (APP) tyrosine …

Recently, measurable peripheral biomarkers in the plasma of patients with Alzheimer's
disease (AD) have gained considerable clinical interest. Several studies have identified one …