Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Transforming growth factor-β1 (TGF-β1) is considered as a crucial mediator in tissue fibrosis
and causes tissue scarring largely by activating its downstream small mother against …

Colorectal cancer (CRC) is the third most common cancer and the fourth most common
cause of cancer mortality worldwide. Colitis-associated colorectal cancer (CAC) is a subtype …

Gut microbiota comprise microorganisms residing in the gastrointestinal tract. Some of these
microbiota are implicated in the progression of colorectal cancer (CRC). Here, we highlight …

Background Tripartite motif-containing (TRIM) 21 is reported to be associated with the
regulation of immune response in gut mucosa. Here we studied the underlying mechanisms …

Transforming growth factor beta (TGF‐β), a multifunctional cytokine, plays critical roles in
immune responses. However, the precise role of TGF‐β in colitis and colitis‐associated …

Abstract Purpose of Review Molecular pathways in colorectal carcinogenesis involve
several complex genetic and epigenetic modulations that cause normal colonic mucosa to …

Abstract circRNAs, as miRNA sponges, participate in many important biological processes.
However, it remains unclear whether circRNAs can regulate lipid metabolism. This study …

Background SMAD1, a central mediator in TGF-β signaling, is involved in a broad range of
biological activities including cell growth, apoptosis, development and immune response …

Drug resistance is a major obstacle leading to treating failure and poor outcome in gastric
cancer (GC). This study explores the interaction between SMAD family member 1 (SMAD1) …