Vascular ageing, characterized by structural and functional changes in blood vessels of
which arterial stiffness and endothelial dysfunction are key components, is associated with …

Nonalcoholic fatty liver disease (NAFLD) is globally prevalent and characterized by
abnormal lipid accumulation in the liver, frequently accompanied by insulin resistance (IR) …

This is a longitudinal single-arm clinical trial aimed to investigate whether exercise training
would modify the whole blood methylation profile in healthy women. A total of 45 subjects …

Acute and chronic physical exercises may enhance the development of statin-related
myopathy. In this context, the recent (2019) guidelines of the European Society of …

Atherosclerosis (AS), a chronic inflammatory vascular disease with lipid metabolism
abnormalities, is one of the major pathological bases of coronary heart disease. As people's …

Purpose Statins are among the most widely prescribed medications worldwide. Considered
the 'gold-standard'treatment for cardiovascular disease (CVD), statins inhibit HMG-CoA …

Background In the USA, the primary cause of death and morbidity continues to be
cardiovascular disease (CVD). Numerous trials have shown that statin medication reduces …

Background: Obesity was often associated with low high-density lipoprotein (HDL)
cholesterol concentration, which is an established cardiovascular risk factor. Objectives: To …

Background Statin therapy is a mainstay of cardiovascular disease (CVD) prevention, but
research shows that statin therapy alone is insufficient for preventing incident CVD and …

Statins are used to prevent and treat atherosclerotic cardiovascular disease, but they also
induce myopathy and mitochondrial dysfunction. Here, we investigated whether exercise …