The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Pulmonary arterial hypertension (PAH) is a rare cardiovascular disorder leading to
pulmonary hypertension and, often fatal, right heart failure. Sex differences in PAH are …

Cell-cell communication systems typically comprise families of ligand and receptor variants
that function together in combinations. Pathway activation depends on the complex way in …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most
debilitating pathology is progressive and cumulative heterotopic ossification (HO) of skeletal …

Heterotopic ossification (HO), defined as the formation of extraskeletal bone in muscle and
soft tissues, is a diverse pathological process caused by either genetic mutations or inciting …

Simple Summary Diffuse midline gliomas (DMGs) remain one of the most devastating
childhood brain tumour types, for which there is currently no known cure. In this review we …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by
episodic yet cumulative heterotopic ossification (HO) of skeletal muscles, tendons …

Activin receptor-like kinase-2 (ALK2) is a type I bone morphogenetic protein (BMP) receptor
which has a role in biological processes that control the development of bone, heart, brain …

Fibrodysplasia ossificans progressiva (FOP), a disorder of congenital skeletal malformations
and progressive extraskeletal ossification, is the most severe form of heterotopic ossification …

Heterotopic ossification (HO) is the formation of ectopic bone that is primarily genetically
driven (fibrodysplasia ossificans progressiva [FOP]) or acquired in the setting of trauma …