Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Growing evidence that a large proportion of apparently non-hereditary sporadic cancers
occur in genetically predisposed individuals has emphasized the need to identify the …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

Mice from various inbred strains consume alcoholic beverages at highly reproducible and
strain–specific levels. While most mice consume alcohol in moderate amounts, C57BL/6J …

The methyl-deficient model of endogenous hepatocarcinogenesis in rodents is unique in
that dietary omission rather than the addition of chemical carcinogens leads to tumor …

The genetic basis of disease susceptibility can be studied by several means, including
research on animal models and epidemiological investigations in humans. The two methods …

The different frequency of hepatocellular carcinoma (HCC) in humans at risk suggests a
polygenic predisposition. However, detection of genetic variants is difficult in genetically …

The challenge of precision medicine is to model complex interactions among DNA variants,
sets of phenotypes, and complex environmental factors and confounders. We have …

There is a vast amount of literature related to mouse liver tumorigenesis generated over the
past 60 years, not all of which has been captured here. The studies reported in this literature …

Smokers have frequently been heard to defend their habit by recounting anecdotes about
relatives or friends who have smoked heavily for many years without developing cancer …