Tumor glycolysis, an essential sweet tooth of tumor cells
Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
[HTML][HTML] Functions and dysfunctions of nitric oxide in brain
P Picón-Pagès, J Garcia-Buendia, FJ Munoz - Biochimica et Biophysica …, 2019 - Elsevier
Nitric oxide (NO) works as a retrograde neurotransmitter in synapses, allows the brain blood
flow and also has important roles in intracellular signaling in neurons from the regulation of …
flow and also has important roles in intracellular signaling in neurons from the regulation of …
Ribosomal proteins: functions beyond the ribosome
Although ribosomal proteins are known for playing an essential role in ribosome assembly
and protein translation, their ribosome-independent functions have also been greatly …
and protein translation, their ribosome-independent functions have also been greatly …
[HTML][HTML] Aberrant protein s-nitrosylation in neurodegenerative diseases
T Nakamura, S Tu, MW Akhtar, CR Sunico, S Okamoto… - Neuron, 2013 - cell.com
S-Nitrosylation is a redox-mediated posttranslational modification that regulates protein
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …
function via covalent reaction of nitric oxide (NO)-related species with a cysteine thiol group …
RNA-binding proteins control gene expression and cell fate in the immune system
M Turner, MD Díaz-Muñoz - Nature immunology, 2018 - nature.com
RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …
system. They interact dynamically with RNA to control its biogenesis and turnover by …
Regulation of protein function and signaling by reversible cysteine S-nitrosylation
NO is a versatile free radical that mediates numerous biological functions within every major
organ system. A molecular pathway by which NO accomplishes functional diversity is the …
organ system. A molecular pathway by which NO accomplishes functional diversity is the …
Aminoacyl‐tRNA synthetases in medicine and disease
Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous 'house‐keeping'enzymes
responsible for charging amino acids to their cognate tRNAs and providing the substrates for …
responsible for charging amino acids to their cognate tRNAs and providing the substrates for …
[HTML][HTML] Critical protein GAPDH and its regulatory mechanisms in cancer cells
JY Zhang, F Zhang, CQ Hong, AE Giuliano… - Cancer biology & …, 2015 - ncbi.nlm.nih.gov
Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), initially identified as a
glycolytic enzyme and considered as a housekeeping gene, is widely used as an internal …
glycolytic enzyme and considered as a housekeeping gene, is widely used as an internal …
Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling
BC Smith, MA Marletta - Current opinion in chemical biology, 2012 - Elsevier
Although it is widely accepted that S-nitrosation occurs in vivo, questions remain regarding S-
nitrosation as a signaling mechanism. The chemistry of S-nitrosation includes NO oxidation …
nitrosation as a signaling mechanism. The chemistry of S-nitrosation includes NO oxidation …
Target-selective protein S-nitrosylation by sequence motif recognition
S-nitrosylation is a ubiquitous protein modification emerging as a principal mechanism of
nitric oxide (NO)-mediated signal transduction and cell function. S-nitrosylases can use NO …
nitric oxide (NO)-mediated signal transduction and cell function. S-nitrosylases can use NO …