Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

Although photoreceptors account for most of the mass and metabolic activity of the retina,
their role in the pathogenesis of diabetic retinopathy has been largely overlooked. Recent …

Emixustat is a visual cycle modulator that has entered clinical trials as a treatment for age-
related macular degeneration (AMD). This molecule has been proposed to inhibit the visual …

Purpose.: Preclinical studies have highlighted retinal oxidative stress in the pathogenesis of
diabetic retinopathy. We evaluated whether a treatment designed to enhance cellular …

Fluid secretion by the ciliary body plays a critical and irreplaceable function in vertebrate
vision by providing nutritive support to the cornea and lens, and by maintaining intraocular …

Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the
1990s as a sensitive approach to high contrast imaging. Following the discovery of …

Recent evidence suggests an important role for outer retinal cells in the pathogenesis of
diabetic retinopathy (DR). Here we investigated the effect of the visual cycle inhibitor …

Caveolin-1 (Cav-1), an integral component of caveolar membrane domains, is expressed in
several retinal cell types, including photoreceptors, retinal vascular endothelial cells, Müller …

Manganese-enhanced MRI (MEMRI) is a powerful non-invasive approach for objectively
measuring either retina or binocular visual brain activity in vivo. In this study, we investigated …

Purpose To test the hypothesis that in rats, intraretinal light-dependent changes on diffusion-
weighted magnetic resonance imaging (MRI) in vivo are consistent with known retinal layer …