Proteome turnover in the spotlight: approaches, applications, and perspectives
In all cells, proteins are continuously synthesized and degraded to maintain protein
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …
homeostasis and modify gene expression levels in response to stimuli. Collectively, the …
Proteostatic regulation in neuronal compartments
SL Giandomenico, B Alvarez-Castelao… - Trends in …, 2022 - cell.com
Neurons continuously adapt to external cues and challenges, including stimulation, plasticity-
inducing signals and aging. These adaptations are critical for neuronal physiology and …
inducing signals and aging. These adaptations are critical for neuronal physiology and …
Stress response silencing by an E3 ligase mutated in neurodegeneration
Stress response pathways detect and alleviate adverse conditions to safeguard cell and
tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts …
tissue homeostasis, yet their prolonged activation induces apoptosis and disrupts …
The translatome of neuronal cell bodies, dendrites, and axons
To form synaptic connections and store information, neurons continuously remodel their
proteomes. The impressive length of dendrites and axons imposes logistical challenges to …
proteomes. The impressive length of dendrites and axons imposes logistical challenges to …
Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins
CM Fusco, K Desch, AR Dörrbaum, M Wang… - Nature …, 2021 - nature.com
Owing to their morphological complexity and dense network connections, neurons modify
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …
their proteomes locally, using mRNAs and ribosomes present in the neuropil (tissue …
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome
Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum
disorder (ASD). However, the role of a major pathway controlling protein synthesis, the …
disorder (ASD). However, the role of a major pathway controlling protein synthesis, the …
A functional dissection of the mRNA and locally synthesized protein population in neuronal dendrites and axons
JD Perez, CM Fusco, EM Schuman - Annual Review of Genetics, 2021 - annualreviews.org
Neurons are characterized by a complex morphology that enables the generation of
subcellular compartments with unique biochemical and biophysical properties, such as …
subcellular compartments with unique biochemical and biophysical properties, such as …
Neuron‐specific translational control shift ensures proteostatic resilience during ER stress
K Wolzak, A Nölle, M Farina, TEM Abbink… - The EMBO …, 2022 - embopress.org
Proteostasis is essential for cellular survival and particularly important for highly specialised
post‐mitotic cells such as neurons. Transient reduction in protein synthesis by protein kinase …
post‐mitotic cells such as neurons. Transient reduction in protein synthesis by protein kinase …
PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress Response
The p53 transcription factor is a master regulator of cellular stress responses inhibited by
repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with …
repressors such as MDM2 and the phosphatase PPM1D. Activation of p53 with …
Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice
GX Zhou, WB Liu, LM Dai, HL Zhu, YW Xiong… - Science of The Total …, 2022 - Elsevier
Cadmium (Cd) is a well-known testicular toxicant. Blood-testis barrier (BTB), a vital part of
testes, which has been reported to be damaged upon Cd exposure. However, the detailed …
testes, which has been reported to be damaged upon Cd exposure. However, the detailed …