Long-acting formulations are designed to reduce dosing frequency and simplify dosing
schedules by providing an extended duration of action. One approach to obtain long-acting …

Long-acting injectable (LAIs) delivery systems sustain the drug therapeutic action in the
body, resulting in reduced dosage regimen, toxicity, and improved patient compliance. Lipid …

Abstract Treatment and prevention of human immunodeficiency virus type one (HIV-1)
infection was transformed through widespread use of antiretroviral therapy (ART). However …

Nanomedicines suffer from poor drug loading and uncontrolled 'burst release'after
administration. Combining prodrug strategies with nanostructured carriers can help to …

In spite of introduction of combination antiretroviral therapy (cART) against human
immunodeficiency virus (HIV) infection; inaccessibility and poor adherence to oral cART …

For two centuries, vaccines have been successful in the fight against viruses, triggering
immune protection. Indeed, the elimination of smallpox, the only infectious disease …

The Human immunodeficiency virus (HIV) is the causative agent of acquired
immunodeficiency syndrome (AIDS), one of the most perilous diseases known to …

Intramuscularly injectable long-acting prodrug-based microcrystals (MCs) are of particular
interest for chronic disease management. Nevertheless, current prevalently used linkers …

Introduction AIDS is one of the world's most serious public health challenges. Protease
inhibitors are key components of AIDS treatment regimen. Ritonavir is a well-known …

Prodrugs are bioreversible drug derivatives which are metabolized into a pharmacologically
active drug following chemical or enzymatic modification. This approach is designed to …