Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

MRI studies have provided valuable insights into the structure and function of neural
networks, particularly in health and in classical neurodegenerative conditions such as …

Saltatory conduction of action potentials along myelinated axons depends on the nodes of
Ranvier—small unmyelinated axonal domains where voltage-gated sodium channels are …

Multiple sclerosis is a debilitating disorder resulting from scattered lesions in the central
nervous system. Because of the high variability of the lesion patterns between patients, it is …

The NaV1. 8 sodium channel, encoded by gene SCN10A, was initially termed sensory
neuron–specific (SNS) due to prominent expression in primary sensory neurons including …

Multiple sclerosis (MS) is an immune-mediated demyelinating disease that alters central
nervous system (CNS) functions. Relapsing-remitting MS (RRMS) is the most common form …

In multiple sclerosis, cerebellar symptoms are associated with clinical impairment and an
increased likelihood of progressive course. Cortical atrophy and synaptic dysfunction play a …

Multiple sclerosis (MS) is a chronic, inflammatory, autoimmune disease of the central
nervous system, and is an important cause of disability in young adults. In genetically …

Background: Complement system activation products are present in areas of
neuroinflammation, demyelination, and neurodegeneration in brains of patients with multiple …

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is
characterized by the progressive loss of oligodendrocytes and myelin and is associated with …