Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

L Xu, Y Li, Y Dai, J Peng - Pharmacological research, 2018 - Elsevier
Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …

Preclinical evidence for the pharmacological actions of naringin: a review

S Bharti, N Rani, B Krishnamurthy, DS Arya - Planta medica, 2014 - thieme-connect.com
Naringin, chemically 4′, 5, 7-trihydroxyflavanone-7-rhamnoglucoside, is a major flavanone
glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. It has been …

Fruit consumption and risk of type 2 diabetes: results from three prospective longitudinal cohort studies

I Muraki, F Imamura, JAE Manson, FB Hu, WC Willett… - Bmj, 2013 - bmj.com
Objective To determine whether individual fruits are differentially associated with risk of type
2 diabetes. Design Prospective longitudinal cohort study. Setting Health professionals in the …

Naringin improves diet-induced cardiovascular dysfunction and obesity in high carbohydrate, high fat diet-fed rats

MA Alam, K Kauter, L Brown - Nutrients, 2013 - mdpi.com
Obesity, insulin resistance, hypertension and fatty liver, together termed metabolic
syndrome, are key risk factors for cardiovascular disease. Chronic feeding of a diet high in …

Berry and citrus phenolic compounds inhibit dipeptidyl peptidase IV: Implications in diabetes management

J Fan, MH Johnson, MA Lila, G Yousef… - Evidence‐Based …, 2013 - Wiley Online Library
Beneficial health effects of fruits and vegetables in the diet have been attributed to their high
flavonoid content. Dipeptidyl peptidase IV (DPP‐IV) is a serine aminopeptidase that is a …

Dipeptidyl peptidase (DPP)-IV inhibitors with antioxidant potential isolated from natural sources: A novel approach for the management of diabetes

AK Singh, D Yadav, N Sharma, JO Jin - Pharmaceuticals, 2021 - mdpi.com
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that is predominantly
caused by insulin resistance or impaired insulin secretion, along with disturbances in …

Food-derived dipeptidyl-peptidase IV inhibitors as a potential approach for glycemic regulation–Current knowledge and future research considerations

IME Lacroix, ECY Li-Chan - Trends in Food Science & Technology, 2016 - Elsevier
Background Diabetes, which currently affects 1 in 11 adults, is considered one of the biggest
worldwide health crises of the 21st century. Over the last decade, synthetic inhibitors of the …

Anthocyanins and proanthocyanidins from blueberry–blackberry fermented beverages inhibit markers of inflammation in macrophages and carbohydrate‐utilizing …

MH Johnson, EG De Mejia, J Fan… - Molecular Nutrition & …, 2013 - Wiley Online Library
Scope Berries are an excellent source of dietary flavonoids which have several health
benefits. Methods and results We evaluated well‐characterized anthocyanins (ANCs) and …

Review of factors affecting citrus polyphenol bioavailability and their importance in designing in vitro, animal, and intervention studies

R Visvanathan, G Williamson - … in food science and food safety, 2022 - Wiley Online Library
Evidence from in vitro, animal, and human studies links citrus fruit consumption with several
health‐promoting effects. However, many in vitro studies disregard bioavailability data, a key …

Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus

N Li, LJ Wang, B Jiang, X Li, C Guo, S Guo… - European Journal of …, 2018 - Elsevier
Diabetes is a fast growing chronic metabolic disorder around the world. Dipeptidyl peptidase-
4 (DPP-4) is a new promising target during type 2 diabetes glycemic control. Thus, a number …