From extraction to advanced analytical methods: The challenges of melanin analysis

IE Pralea, RC Moldovan, AM Petrache, M Ilieș… - International journal of …, 2019 - mdpi.com
The generic term “melanin “describes a black pigment of biological origin, although some
melanins can be brown or even yellow. The pigment is characterized as a heterogenic …

Melanosomes: biogenesis, properties, and evolution of an ancient organelle

L D'Alba, MD Shawkey - Physiological reviews, 2019 - journals.physiology.org
Melanosomes are organelles that produce and store melanin, a widespread biological
pigment with a unique suite of properties including high refractive index, semiconducting …

Unraveling the structure and function of melanin through synthesis

W Cao, X Zhou, NC McCallum, Z Hu… - Journal of the …, 2021 - ACS Publications
Melanin is ubiquitous in living organisms across different biological kingdoms of life, making
it an important, natural biomaterial. Its presence in nature from microorganisms to higher …

Directed self-assembly of herbal small molecules into sustained release hydrogels for treating neural inflammation

J Zheng, R Fan, H Wu, H Yao, Y Yan, J Liu… - Nature …, 2019 - nature.com
Self-assembling natural drug hydrogels formed without structural modification and able to
act as carriers are of interest for biomedical applications. A lack of knowledge about natural …

Melanin biopolymers: Tailoring chemical complexity for materials design

M d'Ischia, A Napolitano, A Pezzella… - Angewandte Chemie …, 2020 - Wiley Online Library
Melanins, a group of dark insoluble pigments found widespread in nature, have become the
focus of growing interest in materials science for various biomedical and technological …

Bird integumentary melanins: biosynthesis, forms, function and evolution

I Galván, F Solano - International Journal of Molecular Sciences, 2016 - mdpi.com
Melanins are the ubiquitous pigments distributed in nature. They are one of the main
pigments responsible for colors in living cells. Birds are among the most diverse animals …

Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease—a review

LR Ranganath, BP Norman… - Journal of inherited …, 2019 - Wiley Online Library
Ochronosis is the process in alkaptonuria (AKU) that causes all the debilitating morbidity.
The process involves selective deposition of homogentisic acid (HGA)‐derived pigment in …

Detection of misdistribution of tyrosinase from melanosomes to lysosomes and its upregulation under psoralen/ultraviolet a with a melanosome-targeting tyrosinase …

J Zhou, W Shi, L Li, Q Gong, X Wu, X Li… - Analytical chemistry, 2016 - ACS Publications
Tyrosinase is regarded as an important biomarker of melanoma cancer, and its metabolism
is closely related to some severe skin diseases such as vitiligo. Since tyrosinase is mainly …

Elucidation of the hierarchical structure of natural eumelanins

M Xiao, W Chen, W Li, J Zhao… - Journal of The …, 2018 - royalsocietypublishing.org
Eumelanin is one of the most ubiquitous pigments in living organisms and plays an
important role in coloration and UV protection. Because eumelanin is highly cross-linked …

Photoprotection versus photodamage: updating an old but still unsolved controversy about melanin

F Solano - Polymer International, 2016 - Wiley Online Library
Melanin is the main pigment in animal skin. It is a heterogeneous polyphenolic molecule
with a generalized absorption in the UV− visible range synthesized in melanocytes, a kind of …