Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of
diseases with different clinical manifestations including cutaneous, mucocutaneous and …

Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of
the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral …

Drug repositioning has received increased attention since the past decade as several
blockbuster drugs have come out of repositioning. Computational approaches are …

A key factor in the successful infection of a mammalian host by Leishmania parasites is their
conversion from extracellular motile promastigotes into intracellular amastigotes. We discuss …

Trypanosomatid parasitic protozoa are divergent from opisthokont models and have evolved
unique mechanisms to regulate their complex life cycles and to adapt to a range of hosts …

ABSTRACT Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone
protein that plays a central role in the folding and maturation of a large array of client …

Protozoan parasite infections, particularly leishmaniasis, present significant public health
challenges in tropical and subtropical regions, affecting socio-economic status and growth …

Widespread resistance against antimalarial drugs thwarts current efforts for controlling the
disease and urges the discovery of new effective treatments. Drug repositioning is …

Protozoan parasites with complex life cycles have high mortality rates affecting billions of
human lives. Available anti-parasitic drugs are inadequate due to variable efficacy, toxicity …

Despite the increasing number of manuscripts describing potential alternative
antileishmanial compounds, little is advancing on translating these knowledges to new …