Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease

H Anderton, IP Wicks, J Silke - Nature Reviews Rheumatology, 2020 - nature.com
Cell death is a vital process that occurs in billions of cells in the human body every day. This
process helps maintain tissue homeostasis, supports recovery from acute injury, deals with …

Molecular crosstalk between apoptosis, necroptosis, and survival signaling

T Vanden Berghe, WJ Kaiser… - Molecular & cellular …, 2015 - Taylor & Francis
Our current knowledge of the molecular mechanisms regulating the signaling pathways
leading to cell survival, cell death, and inflammation has shed light on the tight mutual …

Pathogenic gut flora in patients with chronic heart failure

E Pasini, R Aquilani, C Testa, P Baiardi, S Angioletti… - JACC: Heart Failure, 2016 - jacc.org
Objectives: The goal of this study was to measure the presence of pathogenic gut flora and
intestinal permeability (IP) and their correlations with disease severity, venous blood …

EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

JS Pearson, C Giogha, S Mühlen, U Nachbur… - Nature …, 2017 - nature.com
Cell death signalling pathways contribute to tissue homeostasis and provide innate
protection from infection. Adaptor proteins such as receptor-interacting serine/threonine …

Sex, age, and bacteria: how the intestinal microbiota is modulated in a protandrous hermaphrodite fish

MC Piazzon, F Naya-Català, P Simó-Mirabet… - Frontiers in …, 2019 - frontiersin.org
Intestinal microbiota is key for many host functions, such as digestion, nutrient metabolism,
disease resistance, and immune function. With the growth of the aquaculture industry, there …

SseK1 and SseK3 type III secretion system effectors inhibit NF-κB signaling and necroptotic cell death in Salmonella-infected macrophages

RA Günster, SA Matthews, DW Holden… - Infection and …, 2017 - Am Soc Microbiol
Within host cells such as macrophages, Salmonella enterica translocates virulence (effector)
proteins across its vacuolar membrane via the SPI-2 type III secretion system. Previously, it …

Cellular Aspects of Shigella Pathogenesis: Focus on the Manipulation of Host Cell Processes

SA Killackey, MT Sorbara, SE Girardin - Frontiers in cellular and …, 2016 - frontiersin.org
Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the
study of Shigella has provided a greater understanding of how the host responds to bacterial …

Microbial functional amyloids serve diverse purposes for structure, adhesion and defence

N Shanmugam, MODG Baker, SR Ball, M Steain… - Biophysical …, 2019 - Springer
The functional amyloid state of proteins has in recent years garnered much attention for its
role in serving crucial and diverse biological roles. Amyloid is a protein fold characterised by …

Citrobacter rodentium subverts ATP flux and cholesterol homeostasis in intestinal epithelial cells in vivo

CN Berger, VF Crepin, TI Roumeliotis, JC Wright… - Cell metabolism, 2017 - cell.com
The intestinal epithelial cells (IECs) that line the gut form a robust line of defense against
ingested pathogens. We investigated the impact of infection with the enteric pathogen …

Characteristics of the gut microbiota colonization, inflammatory profile, and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after …

S Huang, N Li, C Liu, T Li, W Wang, L Jiang, Z Li… - Journal of …, 2019 - Springer
Intrauterine growth restriction (IUGR) predisposes newborns to inflammatory and metabolic
disturbance. Disequilibrium of gut microbiota in early life has been implicated in the …