Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

NADPH oxidases (NOX) are enzyme complexes that have received much attention as key
molecules in the development of vascular dysfunction. NOX have the primary function of …

The notion that electrophiles serve as messengers in cell signaling is now widely accepted.
Nonetheless, major issues restrain acceptance of redox homeostasis and redox signaling as …

The endoplasmic reticulum (ER) produces the vast majority of all proteins secreted into the
extracellular space, including hormones and cytokines, as well as cell surface receptors and …

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome. The underlying causes of the disease progression in NAFLD are unclear. Recent …

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …

Background Within cells, there is a narrow concentration threshold that governs whether
reactive oxygen species (ROS) induce toxicity or act as second messengers. Scope of …

Obesity resulting from the delivery of an excess amount of energy to adipose tissue from
glucose or free fatty acids is associated with insulin resistance and adipose tissue …

The peptide hormone insulin is a key regulator of energy metabolism, proliferation and
survival. Binding of insulin to its receptor activates the PI3K/AKT signalling pathway, which …

Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude
and extent of crosstalk between oxidation and other post-translational modifications remains …