In situ gelling formulations are drug delivery systems which typically exist in a liquid form at
room temperature and change into gel state after application to the body in response to …

In situ gelling drug delivery systems have gained enormous attention over the last decade.
They are in a sol-state before administration, and they are capable of forming gels in …

The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

The nasal route has been used for many years for the local treatment of nasal diseases.
More recently, this route has been gaining momentum, due to the possibility of targeting the …

In-situ gel technology is a promising drug delivery strategy that undergoes a'sol to
gel'transition upon administration, providing controlled and prolonged drug release. These …

Addressing disorders related to the central nervous system (CNS) remains a complex
challenge because of the presence of the blood-brain barrier (BBB), which restricts the entry …

In vitro–in vivo correlation (IVIVC) allows prediction of in vivo drug deposition from a nasally
inhaled drug based on in vitro drug measurements. In vitro measurements include physical …

Despite the success of cancer therapeutics, off target cell toxicity prevails as one of the main
challenges of cancer treatment. Exploration of drug delivery methods is a growing field of …

Nasal route of administration offers a unique opportunity of brain targeted drug delivery via
olfactory and trigeminal pathway, providing effective CNS concentrations at lower doses and …

Gellan, an anionic heteropolysaccharide synthesized by Sphingomonas elodea, is an
excellent gelling agent. However, its poor mechanical strength and high gelling temperature …