Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer

RP Johnson, CK Ratnacaram, L Kumar, J Jose - Drug Resistance Updates, 2022 - Elsevier
Prostate cancer (PC) is the most prevalent male urogenital cancer worldwide. PC patients
presenting an advanced or metastatic cancer succumb to the disease, even after therapeutic …

Diosmetin: A dietary flavone as modulator of signaling pathways in cancer progression

W Raza, A Meena, S Luqman - Molecular Carcinogenesis, 2024 - Wiley Online Library
Flavonoids, constituting the most extensive category of polyphenols, founds in a variety of
plants and comprise over 9000 compounds. Diosmetin, O‐methylated flavone (3', 5, 7 …

RETRACTED: Diosmetin inhibits the growth and invasion of gastric cancer by interfering with M2 phenotype macrophage polarization

F Zhang, H Luo - Journal of Biochemical and Molecular …, 2023 - Wiley Online Library
Overturning M2 phenotype macrophage polarization is a promising therapeutic strategy for
gastric cancer (GC). Diosmetin (DIO) is a natural flavonoid with antitumor effect. The aim of …

The role of proinflammatory cytokines and CXC chemokines (CXCL1–CXCL16) in the progression of prostate cancer: insights on their therapeutic management

A Ullah, W Jiao, B Shen - Cellular & Molecular Biology Letters, 2024 - Springer
Reproductive cancers are malignancies that develop in the reproductive organs. One of the
leading cancers affecting the male reproductive system on a global scale is prostate cancer …

Diosmetin as a promising natural therapeutic agent: In vivo, in vitro mechanisms, and clinical studies

Z Sun, K Liu, C Liang, L Wen, J Wu… - Phytotherapy …, 2024 - Wiley Online Library
Diosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other
plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer …

Higher insoluble fiber intake is associated with a lower risk of prostate cancer: results from the PLCO cohort

Y Shen, Q Yuan, M Shi, B Luo - BMC Public Health, 2024 - Springer
Studies regarding the relationship between fiber intake and prostate cancer (PCa) have
conflicting results. Therefore, this study examined the relationship between fiber intake and …

Diosmetin suppresses the progression of ESCC by CDK2/Rb/E2F2/RRM2 pathway and synergies with cisplatin

Y Chen, X Dai, W Chen, Y Qiao, R Bai, X Duan… - Oncogene, 2023 - nature.com
Cisplatin (CDDP) is the first-line drug in the clinical treatment of esophageal squamous cell
carcinoma (ESCC), which has severe nephrotoxicity. Diosmetin (DIOS) can protect kidney …

Diosmetin ameliorates osteoarthritic inflammation in vivo and ECM macromolecules degradation in interleukin-1β-stimulated murine chondrocytes through the Nrf2/NF …

L Qian, C Li, H Liu, H Zhou… - Folia Histochemica et …, 2024 - journals.viamedica.pl
Introduction. Osteoarthritis (OA) is a prevailing degenerative disease in elderly population
and can lead to severe joint dysfunction. Studies have revealed various pharmacological …