Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a
critical regulator of adaptive immune responses. Cbl-b is essential for establishing the …

Regulatory T (Treg) cells play crucial roles in health and disease through their
immunosuppressive properties against various immune cells. In this review we will focus on …

The advent of T-cell-based immunotherapy has remarkably transformed cancer patient
treatment. Despite their success, the currently approved immunotherapeutic protocols still …

Immunotherapy has revolutionized the treatment of cancer. Nevertheless, the majority of
patients do not respond to therapy, meaning a deeper understanding of tumor immune …

The development of liver fibrosis is a result of chronic liver injuries may progress to liver
cirrhosis and liver cancer. In recent years, liver fibrosis has become a major global problem …

Ubiquitination is a form of posttranslational protein modification that affects the activity of
target proteins by regulating their intracellular degradation, trafficking, localization, and …

Immunotherapy options for patients with cancer have emerged following decades of
research on immune responses against tumors. Most treatments in this category harness T …

Introduction Somatostatin (SST) is a peptide hormone primarily synthesized in the digestive
and nervous systems. While its impact on the endocrine system is well-established …

Molecular pathways controlling emigration of mature thymocytes from thymus to the
periphery remain incompletely understood. Here, we show that T cell–specific ablation of …

Cigarette smoke is a common global environmental pollutant. Asthma, the most frequent
allergic airway disease, is related to maternal exposure to cigarette smoke. Our previous …