Genome integrity relies on the accuracy of DNA metabolism, but as appreciated for more
than four decades, transcription enhances mutation and recombination frequencies. More …

With the development and wide usage of CRISPR technology, the presence of R-loop
structures, which consist of an RNA: DNA hybrid and a displaced single strand (ss) DNA …

The transcriptional machinery is thought to dissociate from DNA during replication. Certain
proteins, termed epigenetic marks, must be transferred from parent to daughter DNA strands …

Prokaryotes have evolved a multitude of defense systems to protect against phage
predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here …

Cells have evolved a robust and highly regulated DNA damage response to preserve their
genomic integrity. Although increasing evidence highlights the relevance of RNA regulation …

Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies,
including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant …

Replication forks stalled at co-transcriptional R-loops can be restarted by a mechanism
involving fork cleavage-religation cycles mediated by MUS81 endonuclease and DNA …

Abstract RNA polymerase II (RNAPII) is responsible for the synthesis of a diverse set of RNA
molecules, including protein-coding messenger RNAs (mRNAs) and many short non-coding …

Senataxin is an RNA: DNA helicase that plays an important role in the resolution of RNA:
DNA hybrids (R-loops) formed during transcription. R-loops are involved in the regulation of …

The cell cycle is a crucial biological process that is involved in cell growth, development, and
reproduction. It can be divided into G1, S, G2, and M phases, and each period is closely …